![]() By combining triple-(DG-CA3-CA1) ensemble recordings and optogenetic interventions in behaving mice, we show that abDGCs constitute a subset of high-firing-rate neurons with enhanced activity responses to novelty and strong modulation by theta oscillations. Here, we show that abDGCs promote sparser hippocampal population spiking during mnemonic processing of novel stimuli. Intriguingly, the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan, but their contribution to downstream firing dynamics remains unclear. The dentate gyrus (DG) gates neocortical information flow to the hippocampus.
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